RESEARCH SUMMARY- LASER

Ihsan MFR. Low-level laser therapy accelerates collateral circulation and enhances microcirculation. Photomedicine and Laser Surgery 2005; 23(3): 289-294.
• The results indicated that LLLT accelerated collateral circulation and enhanced microcirculation and seemed to be unique in the normalization of the functional features of the injured area, which could lead to occlusion of the regional blood vessels.
• Numerous collateral blood vessels proliferated the area, with marked increases in the diameters of the original blood vessels.
• Low-level lasers also activate ATP, ATPase, and the conversion of adenosine triphosphate to adenosine. Adenosine stimulates the conversion of cAMPtonitricoxide (NO) or the vascular endothelial growth factor (VEGF). • Adenosine, Growth Hormone, Fibroblast Growth Factor, and VEGF are angiogenic factors and promote new vessel growth in the same manner

Schindl A et al. Low-intensity laser irradiation improves skin circulation in patients with diabetic microangiopathy. Diabetes Care 1998; 21(4): 580-584.
• The data from this first randomized double-blind placebo-controlled clinical trial demonstrate an increase in skin microcirculation due to athermic laser irradiation in patients with diabetic microangiopathy.

Karu TI, Pyatibrat LV, Afaanasyeva NI. Cellular e ects of low power laser therapy can be
mediated by nitric oxide. Lasers in Surgery and Medicine 2005; 36: 307-314.
• NO2 is involved in the radiation-induced mesenteric arteriolar vasodilatation and the subsequent increase in the microcirculatory blood flow. Irradiation at di erent wavelengths induces vasodilatation in blood-perfused vessels but not in saline-perfused ones. It was suggested that NO2–hemoglobin might serve as a light-sensitive store of NO2 in red blood cells from which it was released by irradiation